hrp0089p2-p123 | Fat, Metabolism and Obesity P2 | ESPE2018

Allopurinol Ameliorates Non-Alcoholic Fatty Liver Disease in Rats

Anil Korkmaz Huseyin , Aktug Huseyin , Atila Dincer , Barisik Vatan , Arslan Nur , Erbas Oytun

Background: Hyperuricemia has been found to be associated with non-alcoholic fatty liver disease (NAFLD).Aim: The aim of this study was to evaluate whether allopurinol affects the course of experimental NAFLD in rats.Study Design: Mature, albino Sprague Dawley rats were fed water containing 30% fructose without ethanol for up to 8 weeks. After demonstration of steatosis in the 8th week, either allopurinol or saline was administered...